Cardiac Arrest Treatment With Adrenaline : Link to Brain Damage  in patients

A recent study suggests  that Cardiac arrest patients who are treated with adrenaline  will most likely  have severe brain damage if they survive.

The study involving 8,000 patients found that though getting  an  adrenaline  shot slightly increases the chances of  your survival, you may  more likely  damage your brain.

Cardiac arrest
Cardiac arrest

A cardiac arrest occurs when your heart suddenly stops pumping blood around your body.

it is usually treated quickly with CPR(cardiopulmonary resuscitation )and defibrillation then adrenaline is  used when normal treatments fail.

For this new trial, cardiac arrest patients from England and Wales were given either an injection of adrenaline or a saline solution  (control variable) by paramedics, who did not know which they were giving.


Result from the three-y

ear study  show that,of the  about 4000 patients given adrenaline,

130 (3.2%) were alive 30 days after treatment compared with 94 (2.4%) of the 3,995 patients who took the saline solution  treatment.

However, in the adrenaline group 39 of those who were discharged from hospital had severe brain damage compared with 16 who were given a dummy solution.

Medics performing defibrillation on patient
Cardiac arrest treatment

One of the paper’s authors, from Warwick Medical School, Prof Gavin Perkins said: “Patients may be less willing to accept treatments

if the chances of recovery are small or the risk of survival with severe brain damage is high.

“The findings of this trial will require careful consideration by the wider community and those responsible for clinical practice guidelines for cardiac arrest.”

Authors of the study, published in the New England Journal of Medicine, said it was not yet fully understood why those who received adrenaline had more brain damage.

One of their theories  suggests that though adrenaline increases blood flow in large blood vessels,

It reduces it in very small vessels, which Prof Gavin Perkins worsen brain damage caused by a cardiac arrest.

Dr David Nunan, senior researcher at the Centre for Evidence-Based Medicine at the University of Oxford, said the “landmark trial” would change the way people are treated.

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